2. Epigenetics
  3. Histone Methyltransferase
  4. LLY-507

LLY-507 是一种有效、选择性的赖氨酸甲基转移酶 SMYD2 抑制剂。LLY-507 能有效抑制 SMYD2 甲基化 p53 肽的能力，其 IC50 <15 nM。LLY-507 是一种有价值的化学探针，用于解析 SMYD2 在癌症和其他生物过程中的功能。

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LLY-507

LLY-507 Chemical Structure

CAS No. : 1793053-37-8

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规格 价格 是否有货 数量
10 mM * 1 mL in DMSO ￥1100
In-stock
1 mg ￥395
In-stock
5 mg ￥870
In-stock
10 mg ￥1550
In-stock
25 mg ￥3500
In-stock
50 mg 现货 询价
100 mg   询价  
200 mg   询价  

* Please select Quantity before adding items.

Customer Review

LLY-507 相关抗体

Top Publications Citing Use of Products

    LLY-507 purchased from MCE. Usage Cited in: Cell Death Dis. 2018 Jan 26;9(2):129.  [Abstract]

    The effects of treatment with the indicated epigenetic inhibitors on cleaved PARP (Clv-PARP) expression in both PC9/ER and HCC827/ER cells. β-actin is used as a loading control.

    查看 Histone Methyltransferase 亚型特异性产品:

    查看所有亚型
    EZH1 EZH2 DOT1L SMYD2 SMYD3 SUV39H2/KMT1B EHMT2/G9a/KMT1C EHMT1/GLP/KMT1D ASH1L/KMT2H SETDB1/KMT2G SETD2/KMT3A NSD2/MMSET/WHSC1 SETD7/KMT7 SETD8/KMT5A PRMT1 PRMT3 PRMT4 PRMT5 PRMT6 PRMT7 PRMT8

    • 生物活性

    • 纯度 & 产品资料

    • 参考文献

    生物活性

    LLY-507 is a potent and selective inhibitor of protein-lysine methyltransferase SMYD2. LLY-507 potently inhibits the ability of SMYD2 to methylate p53 peptide with an IC50 <15 nM. LLY-507 serves as a valuable chemical probe to aid in the dissection of SMYD2 function in cancer and other biological processes[1].

    IC50 & Target[1]

    SMYD2

    <15 nM (IC50)

    细胞效力
    (Cellular Effect)
    Cell Line Type Value Description References
    5637 IC50
    6.75 μM
    Compound: Chemical probe: LLY-507
    Antiproliferative activity against human 5637 cells after 10 days
    Antiproliferative activity against human 5637 cells after 10 days
    		[PMID: 29856759]
    639-V IC50
    1.14 μM
    Compound: Chemical probe: LLY-507
    Antiproliferative activity against human 639-V cells after 10 days
    Antiproliferative activity against human 639-V cells after 10 days
    		[PMID: 29856759]
    647-V IC50
    1.48 μM
    Compound: Chemical probe: LLY-507
    Antiproliferative activity against human 647-V cells after 10 days
    Antiproliferative activity against human 647-V cells after 10 days
    		[PMID: 29856759]
    769-P IC50
    2.76 μM
    Compound: Chemical probe: LLY-507
    Antiproliferative activity against human 769-P cells after 10 days
    Antiproliferative activity against human 769-P cells after 10 days
    		[PMID: 29856759]
    786-0 IC50
    2.1 μM
    Compound: Chemical probe: LLY-507
    Antiproliferative activity against human 786-0 cells after 10 days
    Antiproliferative activity against human 786-0 cells after 10 days
    		[PMID: 29856759]
    A 172 IC50
    1.96 μM
    Compound: Chemical probe: LLY-507
    Antiproliferative activity against human A-172 cells after 10 days
    Antiproliferative activity against human A-172 cells after 10 days
    		[PMID: 29856759]
    A-375 IC50
    1.91 μM
    Compound: Chemical probe: LLY-507
    Antiproliferative activity against human A-375 cells after 10 days
    Antiproliferative activity against human A-375 cells after 10 days
    		[PMID: 29856759]
    A-427 IC50
    1.34 μM
    Compound: Chemical probe: LLY-507
    Antiproliferative activity against human A-427 cells after 10 days
    Antiproliferative activity against human A-427 cells after 10 days
    		[PMID: 29856759]
    A-431 IC50
    6.35 μM
    Compound: Chemical probe: LLY-507
    Antiproliferative activity against human A-431 cells after 10 days
    Antiproliferative activity against human A-431 cells after 10 days
    		[PMID: 29856759]
    A101D IC50
    1.23 μM
    Compound: Chemical probe: LLY-507
    Antiproliferative activity against human A101D cells after 10 days
    Antiproliferative activity against human A101D cells after 10 days
    		[PMID: 29856759]
    A204 IC50
    1.35 μM
    Compound: Chemical probe: LLY-507
    Antiproliferative activity against human A204 cells after 10 days
    Antiproliferative activity against human A204 cells after 10 days
    		[PMID: 29856759]
    A498 IC50
    2.01 μM
    Compound: Chemical probe: LLY-507
    Antiproliferative activity against human A498 cells after 10 days
    Antiproliferative activity against human A498 cells after 10 days
    		[PMID: 29856759]
    A549 IC50
    3.39 μM
    Compound: Chemical probe: LLY-507
    Antiproliferative activity against human A549 cells after 10 days
    Antiproliferative activity against human A549 cells after 10 days
    		[PMID: 29856759]
    A673 IC50
    2.03 μM
    Compound: Chemical probe: LLY-507
    Antiproliferative activity against human A673 cells after 10 days
    Antiproliferative activity against human A673 cells after 10 days
    		[PMID: 29856759]
    ACHN IC50
    3.21 μM
    Compound: Chemical probe: LLY-507
    Antiproliferative activity against human ACHN cells after 10 days
    Antiproliferative activity against human ACHN cells after 10 days
    		[PMID: 29856759]
    AGS IC50
    1.27 μM
    Compound: Chemical probe: LLY-507
    Antiproliferative activity against human AGS cells after 10 days
    Antiproliferative activity against human AGS cells after 10 days
    		[PMID: 29856759]
    AGS IC50
    5.5 μM
    Compound: LLY-507
    Antiproliferative activity against human AGS cells
    Antiproliferative activity against human AGS cells
    		[PMID: 33011288]
    AN3-CA IC50
    2.42 μM
    Compound: Chemical probe: LLY-507
    Antiproliferative activity against human AN3-CA cells after 10 days
    Antiproliferative activity against human AN3-CA cells after 10 days
    		[PMID: 29856759]
    ARH-77 IC50
    0.78 μM
    Compound: Chemical probe: LLY-507
    Antiproliferative activity against human ARH-77 cells after 10 days
    Antiproliferative activity against human ARH-77 cells after 10 days
    		[PMID: 29856759]
    ASPC1 IC50
    3.01 μM
    Compound: Chemical probe: LLY-507
    Antiproliferative activity against human ASPC1 cells after 10 days
    Antiproliferative activity against human ASPC1 cells after 10 days
    		[PMID: 29856759]
    AU565 IC50
    1.25 μM
    Compound: Chemical probe: LLY-507
    Antiproliferative activity against human AU565 cells after 10 days
    Antiproliferative activity against human AU565 cells after 10 days
    		[PMID: 29856759]
    BC IC50
    1.5 μM
    Compound: 3; LLY-507
    Antitumor activity against human BC cells assessed as inhibition of cell proliferation incubated for 3 to 7 days by CellTiter-Glo assay
    Antitumor activity against human BC cells assessed as inhibition of cell proliferation incubated for 3 to 7 days by CellTiter-Glo assay
    		[PMID: 35914250]
    BFTC-905 IC50
    2.5 μM
    Compound: Chemical probe: LLY-507
    Antiproliferative activity against human BFTC-905 cells after 10 days
    Antiproliferative activity against human BFTC-905 cells after 10 days
    		[PMID: 29856759]
    BHT-101 IC50
    1.43 μM
    Compound: Chemical probe: LLY-507
    Antiproliferative activity against human BHT-101 cells after 10 days
    Antiproliferative activity against human BHT-101 cells after 10 days
    		[PMID: 29856759]
    BPH-1 IC50
    3.49 μM
    Compound: Chemical probe: LLY-507
    Antiproliferative activity against human BPH-1 cells after 10 days
    Antiproliferative activity against human BPH-1 cells after 10 days
    		[PMID: 29856759]
    BT-20 IC50
    3.35 μM
    Compound: Chemical probe: LLY-507
    Antiproliferative activity against human BT-20 cells after 10 days
    Antiproliferative activity against human BT-20 cells after 10 days
    		[PMID: 29856759]
    BT-474 IC50
    2.94 μM
    Compound: Chemical probe: LLY-507
    Antiproliferative activity against human BT-474 cells after 10 days
    Antiproliferative activity against human BT-474 cells after 10 days
    		[PMID: 29856759]
    BT-549 IC50
    3.29 μM
    Compound: Chemical probe: LLY-507
    Antiproliferative activity against human BT-549 cells after 10 days
    Antiproliferative activity against human BT-549 cells after 10 days
    		[PMID: 29856759]
    BV-173 IC50
    1.33 μM
    Compound: Chemical probe: LLY-507
    Antiproliferative activity against human BV-173 cells after 10 days
    Antiproliferative activity against human BV-173 cells after 10 days
    		[PMID: 29856759]
    BXPC-3 IC50
    2.87 μM
    Compound: Chemical probe: LLY-507
    Antiproliferative activity against human BXPC-3 cells after 10 days
    Antiproliferative activity against human BXPC-3 cells after 10 days
    		[PMID: 29856759]
    BeWo IC50
    2.88 μM
    Compound: Chemical probe: LLY-507
    Antiproliferative activity against human BeWo cells after 10 days
    Antiproliferative activity against human BeWo cells after 10 days
    		[PMID: 29856759]
    C-33-A IC50
    3.23 μM
    Compound: Chemical probe: LLY-507
    Antiproliferative activity against human C-33-A cells after 10 days
    Antiproliferative activity against human C-33-A cells after 10 days
    		[PMID: 29856759]
    C-4-II IC50
    1.78 μM
    Compound: Chemical probe: LLY-507
    Antiproliferative activity against human C-4-II cells after 10 days
    Antiproliferative activity against human C-4-II cells after 10 days
    		[PMID: 29856759]
    C32 IC50
    1.73 μM
    Compound: Chemical probe: LLY-507
    Antiproliferative activity against human C32 cells after 10 days
    Antiproliferative activity against human C32 cells after 10 days
    		[PMID: 29856759]
    CAKI-1 IC50
    2.79 μM
    Compound: Chemical probe: LLY-507
    Antiproliferative activity against human CAKI-1 cells after 10 days
    Antiproliferative activity against human CAKI-1 cells after 10 days
    		[PMID: 29856759]
    CAKI-2 IC50
    1.22 μM
    Compound: Chemical probe: LLY-507
    Antiproliferative activity against human CAKI-2 cells after 10 days
    Antiproliferative activity against human CAKI-2 cells after 10 days
    		[PMID: 29856759]
    CAL-27 IC50
    2.52 μM
    Compound: Chemical probe: LLY-507
    Antiproliferative activity against human CAL-27 cells after 10 days
    Antiproliferative activity against human CAL-27 cells after 10 days
    		[PMID: 29856759]
    CAL-62 IC50
    2.07 μM
    Compound: Chemical probe: LLY-507
    Antiproliferative activity against human CAL-62 cells after 10 days
    Antiproliferative activity against human CAL-62 cells after 10 days
    		[PMID: 29856759]
    CAMA-1 IC50
    2.93 μM
    Compound: Chemical probe: LLY-507
    Antiproliferative activity against human CAMA-1 cells after 10 days
    Antiproliferative activity against human CAMA-1 cells after 10 days
    		[PMID: 29856759]
    CAPAN-1 IC50
    5.09 μM
    Compound: Chemical probe: LLY-507
    Antiproliferative activity against human CAPAN-1 cells after 10 days
    Antiproliferative activity against human CAPAN-1 cells after 10 days
    		[PMID: 29856759]
    CCF-STTG1 IC50
    5.82 μM
    Compound: Chemical probe: LLY-507
    Antiproliferative activity against human CCF-STTG1 cells after 10 days
    Antiproliferative activity against human CCF-STTG1 cells after 10 days
    		[PMID: 29856759]
    CCRF-CEM IC50
    1.79 μM
    Compound: Chemical probe: LLY-507
    Antiproliferative activity against human CCRF-CEM cells after 10 days
    Antiproliferative activity against human CCRF-CEM cells after 10 days
    		[PMID: 29856759]
    CFPAC-1 IC50
    1.48 μM
    Compound: Chemical probe: LLY-507
    Antiproliferative activity against human CFPAC-1 cells after 10 days
    Antiproliferative activity against human CFPAC-1 cells after 10 days
    		[PMID: 29856759]
    CGTH-W-1 IC50
    2.87 μM
    Compound: Chemical probe: LLY-507
    Antiproliferative activity against human CGTH-W-1 cells after 10 days
    Antiproliferative activity against human CGTH-W-1 cells after 10 days
    		[PMID: 29856759]
    CHL-1 IC50
    2.57 μM
    Compound: Chemical probe: LLY-507
    Antiproliferative activity against human CHL-1 cells after 10 days
    Antiproliferative activity against human CHL-1 cells after 10 days
    		[PMID: 29856759]
    CHP-212 IC50
    2.1 μM
    Compound: Chemical probe: LLY-507
    Antiproliferative activity against human CHP-212 cells after 10 days
    Antiproliferative activity against human CHP-212 cells after 10 days
    		[PMID: 29856759]
    COLO 201 IC50
    1.06 μM
    Compound: Chemical probe: LLY-507
    Antiproliferative activity against human COLO201 cells after 10 days
    Antiproliferative activity against human COLO201 cells after 10 days
    		[PMID: 29856759]
    COLO 205 IC50
    0.944 μM
    Compound: Chemical probe: LLY-507
    Antiproliferative activity against human COLO 205 cells after 10 days
    Antiproliferative activity against human COLO 205 cells after 10 days
    		[PMID: 29856759]
    COLO 320DM IC50
    2.11 μM
    Compound: Chemical probe: LLY-507
    Antiproliferative activity against human COLO 320DM cells after 10 days
    Antiproliferative activity against human COLO 320DM cells after 10 days
    		[PMID: 29856759]
    COLO-320-HSR IC50
    2.74 μM
    Compound: Chemical probe: LLY-507
    Antiproliferative activity against human COLO 320HSR cells after 10 days
    Antiproliferative activity against human COLO 320HSR cells after 10 days
    		[PMID: 29856759]
    COLO-829 IC50
    1.75 μM
    Compound: Chemical probe: LLY-507
    Antiproliferative activity against human COLO-829 cells after 10 days
    Antiproliferative activity against human COLO-829 cells after 10 days
    		[PMID: 29856759]
    COR-L105 IC50
    1.11 μM
    Compound: Chemical probe: LLY-507
    Antiproliferative activity against human COR-L105 cells after 10 days
    Antiproliferative activity against human COR-L105 cells after 10 days
    		[PMID: 29856759]
    COR-L23 IC50
    2.21 μM
    Compound: Chemical probe: LLY-507
    Antiproliferative activity against human COR-L23 cells after 10 days
    Antiproliferative activity against human COR-L23 cells after 10 days
    		[PMID: 29856759]
    CRO-AP2 IC50
    2.26 μM
    Compound: Chemical probe: LLY-507
    Antiproliferative activity against human CRO-AP2 cells after 10 days
    Antiproliferative activity against human CRO-AP2 cells after 10 days
    		[PMID: 29856759]
    CWR22R IC50
    1.06 μM
    Compound: Chemical probe: LLY-507
    Antiproliferative activity against human 22Rv1 cells after 10 days
    Antiproliferative activity against human 22Rv1 cells after 10 days
    		[PMID: 29856759]
    Calu-1 IC50
    2.85 μM
    Compound: Chemical probe: LLY-507
    Antiproliferative activity against human Calu-1 cells after 10 days
    Antiproliferative activity against human Calu-1 cells after 10 days
    		[PMID: 29856759]
    Calu-6 IC50
    3.68 μM
    Compound: Chemical probe: LLY-507
    Antiproliferative activity against human Calu-6 cells after 10 days
    Antiproliferative activity against human Calu-6 cells after 10 days
    		[PMID: 29856759]
    Capan-2 IC50
    1.57 μM
    Compound: Chemical probe: LLY-507
    Antiproliferative activity against human Capan2 cells after 10 days
    Antiproliferative activity against human Capan2 cells after 10 days
    		[PMID: 29856759]
    ChaGo-K-1 IC50
    1.23 μM
    Compound: Chemical probe: LLY-507
    Antiproliferative activity against human ChaGo-K-1 cells after 10 days
    Antiproliferative activity against human ChaGo-K-1 cells after 10 days
    		[PMID: 29856759]
    D283 Med IC50
    2.51 μM
    Compound: Chemical probe: LLY-507
    Antiproliferative activity against human D283 Med cells after 10 days
    Antiproliferative activity against human D283 Med cells after 10 days
    		[PMID: 29856759]
    DB IC50
    1.17 μM
    Compound: Chemical probe: LLY-507
    Antiproliferative activity against human DB cells after 10 days
    Antiproliferative activity against human DB cells after 10 days
    		[PMID: 29856759]
    DBTRG-05MG IC50
    1.72 μM
    Compound: Chemical probe: LLY-507
    Antiproliferative activity against human DBTRG-05MG cells after 10 days
    Antiproliferative activity against human DBTRG-05MG cells after 10 days
    		[PMID: 29856759]
    DK-MG IC50
    6.42 μM
    Compound: Chemical probe: LLY-507
    Antiproliferative activity against human DK-MG cells after 10 days
    Antiproliferative activity against human DK-MG cells after 10 days
    		[PMID: 29856759]
    DLD-1 IC50
    3.4 μM
    Compound: Chemical probe: LLY-507
    Antiproliferative activity against human DLD-1 cells after 10 days
    Antiproliferative activity against human DLD-1 cells after 10 days
    		[PMID: 29856759]
    DMS-114 IC50
    2.33 μM
    Compound: Chemical probe: LLY-507
    Antiproliferative activity against human DMS-114 cells after 10 days
    Antiproliferative activity against human DMS-114 cells after 10 days
    		[PMID: 29856759]
    DMS-273 IC50
    0.987 μM
    Compound: Chemical probe: LLY-507
    Antiproliferative activity against human DMS-273 cells after 10 days
    Antiproliferative activity against human DMS-273 cells after 10 days
    		[PMID: 29856759]
    DMS-53 IC50
    3.17 μM
    Compound: Chemical probe: LLY-507
    Antiproliferative activity against human DMS-53 cells after 10 days
    Antiproliferative activity against human DMS-53 cells after 10 days
    		[PMID: 29856759]
    DOHH-2 IC50
    0.263 μM
    Compound: Chemical probe: LLY-507
    Antiproliferative activity against human DOHH-2 cells after 10 days
    Antiproliferative activity against human DOHH-2 cells after 10 days
    		[PMID: 29856759]
    DU-145 IC50
    4.13 μM
    Compound: Chemical probe: LLY-507
    Antiproliferative activity against human DU-145 cells after 10 days
    Antiproliferative activity against human DU-145 cells after 10 days
    		[PMID: 29856759]
    Daoy IC50
    3.67 μM
    Compound: Chemical probe: LLY-507
    Antiproliferative activity against human Daoy cells after 10 days
    Antiproliferative activity against human Daoy cells after 10 days
    		[PMID: 29856759]
    Daudi IC50
    0.857 μM
    Compound: Chemical probe: LLY-507
    Antiproliferative activity against human Daudi cells after 10 days
    Antiproliferative activity against human Daudi cells after 10 days
    		[PMID: 29856759]
    Detroit 562 IC50
    1.75 μM
    Compound: Chemical probe: LLY-507
    Antiproliferative activity against human Detroit 562 cells after 10 days
    Antiproliferative activity against human Detroit 562 cells after 10 days
    		[PMID: 29856759]
    DoTc2-4510 IC50
    1.07 μM
    Compound: Chemical probe: LLY-507
    Antiproliferative activity against human DoTc2-4510 cells after 10 days
    Antiproliferative activity against human DoTc2-4510 cells after 10 days
    		[PMID: 29856759]
    EB-3 IC50
    0.329 μM
    Compound: Chemical probe: LLY-507
    Antiproliferative activity against human EB-3 cells after 10 days
    Antiproliferative activity against human EB-3 cells after 10 days
    		[PMID: 29856759]
    EFM-19 IC50
    2.68 μM
    Compound: Chemical probe: LLY-507
    Antiproliferative activity against human EFM-19 cells after 10 days
    Antiproliferative activity against human EFM-19 cells after 10 days
    		[PMID: 29856759]
    EM-2 IC50
    2.22 μM
    Compound: Chemical probe: LLY-507
    Antiproliferative activity against human EM-2 cells after 10 days
    Antiproliferative activity against human EM-2 cells after 10 days
    		[PMID: 29856759]
    ES-2 IC50
    1.32 μM
    Compound: Chemical probe: LLY-507
    Antiproliferative activity against human ES2 cells after 10 days
    Antiproliferative activity against human ES2 cells after 10 days
    		[PMID: 29856759]
    FaDu IC50
    2.36 μM
    Compound: Chemical probe: LLY-507
    Antiproliferative activity against human FaDu cells after 10 days
    Antiproliferative activity against human FaDu cells after 10 days
    		[PMID: 29856759]
    G-401 IC50
    0.905 μM
    Compound: Chemical probe: LLY-507
    Antiproliferative activity against human G-401 cells after 10 days
    Antiproliferative activity against human G-401 cells after 10 days
    		[PMID: 29856759]
    G-402 IC50
    2.19 μM
    Compound: Chemical probe: LLY-507
    Antiproliferative activity against human G-402 cells after 10 days
    Antiproliferative activity against human G-402 cells after 10 days
    		[PMID: 29856759]
    H4 IC50
    1.88 μM
    Compound: Chemical probe: LLY-507
    Antiproliferative activity against human H4 cells after 10 days
    Antiproliferative activity against human H4 cells after 10 days
    		[PMID: 29856759]
    HCT-116 IC50
    2.66 μM
    Compound: Chemical probe: LLY-507
    Antiproliferative activity against human HCT-116 cells after 10 days
    Antiproliferative activity against human HCT-116 cells after 10 days
    		[PMID: 29856759]
    HCT-15 IC50
    1.7 μM
    Compound: Chemical probe: LLY-507
    Antiproliferative activity against human HCT-15 cells after 10 days
    Antiproliferative activity against human HCT-15 cells after 10 days
    		[PMID: 29856759]
    HCT-8 IC50
    2.52 μM
    Compound: Chemical probe: LLY-507
    Antiproliferative activity against human HCT-8 cells after 10 days
    Antiproliferative activity against human HCT-8 cells after 10 days
    		[PMID: 29856759]
    HEC-1-A IC50
    1.05 μM
    Compound: Chemical probe: LLY-507
    Antiproliferative activity against human HEC-1-A cells after 10 days
    Antiproliferative activity against human HEC-1-A cells after 10 days
    		[PMID: 29856759]
    HEL 92.1.7 IC50
    3.53 μM
    Compound: Chemical probe: LLY-507
    Antiproliferative activity against human HEL 92.1.7 cells after 10 days
    Antiproliferative activity against human HEL 92.1.7 cells after 10 days
    		[PMID: 29856759]
    HLE IC50
    1.88 μM
    Compound: Chemical probe: LLY-507
    Antiproliferative activity against human HLE cells after 10 days
    Antiproliferative activity against human HLE cells after 10 days
    		[PMID: 29856759]
    HOS IC50
    2.13 μM
    Compound: Chemical probe: LLY-507
    Antiproliferative activity against human HOS cells after 10 days
    Antiproliferative activity against human HOS cells after 10 days
    		[PMID: 29856759]
    HPAF-II IC50
    1.6 μM
    Compound: Chemical probe: LLY-507
    Antiproliferative activity against human HPAF-II cells after 10 days
    Antiproliferative activity against human HPAF-II cells after 10 days
    		[PMID: 29856759]
    HT IC50
    1.93 μM
    Compound: Chemical probe: LLY-507
    Antiproliferative activity against human HT cells after 10 days
    Antiproliferative activity against human HT cells after 10 days
    		[PMID: 29856759]
    HT-1080 IC50
    1.98 μM
    Compound: Chemical probe: LLY-507
    Antiproliferative activity against human HT-1080 cells after 10 days
    Antiproliferative activity against human HT-1080 cells after 10 days
    		[PMID: 29856759]
    HT-1376 IC50
    2.35 μM
    Compound: Chemical probe: LLY-507
    Antiproliferative activity against human HT-1376 cells after 10 days
    Antiproliferative activity against human HT-1376 cells after 10 days
    		[PMID: 29856759]
    HT-29 IC50
    1.26 μM
    Compound: Chemical probe: LLY-507
    Antiproliferative activity against human HT-29 cells after 10 days
    Antiproliferative activity against human HT-29 cells after 10 days
    		[PMID: 29856759]
    HT-3 IC50
    3.27 μM
    Compound: Chemical probe: LLY-507
    Antiproliferative activity against human HT-3 cells after 10 days
    Antiproliferative activity against human HT-3 cells after 10 days
    		[PMID: 29856759]
    HT1197 IC50
    1.56 μM
    Compound: Chemical probe: LLY-507
    Antiproliferative activity against human HT1197 cells after 10 days
    Antiproliferative activity against human HT1197 cells after 10 days
    		[PMID: 29856759]
    HUH-6-clone5 IC50
    1.34 μM
    Compound: Chemical probe: LLY-507
    Antiproliferative activity against human HUH-6-clone5 cells after 10 days
    Antiproliferative activity against human HUH-6-clone5 cells after 10 days
    		[PMID: 29856759]
    HeLa IC50
    2.96 μM
    Compound: Chemical probe: LLY-507
    Antiproliferative activity against human HeLa cells after 10 days
    Antiproliferative activity against human HeLa cells after 10 days
    		[PMID: 29856759]
    Hep 3B2 IC50
    0.3 μM
    Compound: Chemical Probe: LLY-507
    Antiproliferative activity against human Hep3B cells measured after 7 day by celltitre-glo luminescent assay
    Antiproliferative activity against human Hep3B cells measured after 7 day by celltitre-glo luminescent assay
    		[PMID: 25825497]
    Hep 3B2 IC50
    1.5 μM
    Compound: Chemical Probe: LLY-507
    Antiproliferative activity against human Hep3B cells measured after 3 to 4 day by celltitre-glo luminescent assay
    Antiproliferative activity against human Hep3B cells measured after 3 to 4 day by celltitre-glo luminescent assay
    		[PMID: 25825497]
    HepG2 IC50
    0.3 μM
    Compound: Chemical Probe: LLY-507
    Antiproliferative activity against human HepG2 cells measured after 7 day by celltitre-glo luminescent assay
    Antiproliferative activity against human HepG2 cells measured after 7 day by celltitre-glo luminescent assay
    		[PMID: 25825497]
    HepG2 IC50
    1.5 μM
    Compound: Chemical Probe: LLY-507
    Antiproliferative activity against human HepG2 cells measured after 3 to 4 day by celltitre-glo luminescent assay
    Antiproliferative activity against human HepG2 cells measured after 3 to 4 day by celltitre-glo luminescent assay
    		[PMID: 25825497]
    HepG2 IC50
    2.35 μM
    Compound: Chemical probe: LLY-507
    Antiproliferative activity against human HepG2 cells after 10 days
    Antiproliferative activity against human HepG2 cells after 10 days
    		[PMID: 29856759]
    Hs 294T IC50
    2.48 μM
    Compound: Chemical probe: LLY-507
    Antiproliferative activity against human Hs 294T cells after 10 days
    Antiproliferative activity against human Hs 294T cells after 10 days
    		[PMID: 29856759]
    Hs 695T IC50
    6.65 μM
    Compound: Chemical probe: LLY-507
    Antiproliferative activity against human Hs 695T cells after 10 days
    Antiproliferative activity against human Hs 695T cells after 10 days
    		[PMID: 29856759]
    Hs 766 IC50
    2.75 μM
    Compound: Chemical probe: LLY-507
    Antiproliferative activity against human Hs766T cells after 10 days
    Antiproliferative activity against human Hs766T cells after 10 days
    		[PMID: 29856759]
    Hs-578T IC50
    6.14 μM
    Compound: Chemical probe: LLY-507
    Antiproliferative activity against human Hs 578T cells after 10 days
    Antiproliferative activity against human Hs 578T cells after 10 days
    		[PMID: 29856759]
    Hs746T IC50
    4.29 μM
    Compound: Chemical probe: LLY-507
    Antiproliferative activity against human Hs746T cells after 10 days
    Antiproliferative activity against human Hs746T cells after 10 days
    		[PMID: 29856759]
    HuCCT-1 IC50
    1.24 μM
    Compound: Chemical probe: LLY-507
    Antiproliferative activity against human HuCCT-1 cells after 10 days
    Antiproliferative activity against human HuCCT-1 cells after 10 days
    		[PMID: 29856759]
    HuP-T4 IC50
    3.48 μM
    Compound: Chemical probe: LLY-507
    Antiproliferative activity against human HuP-T4 cells after 10 days
    Antiproliferative activity against human HuP-T4 cells after 10 days
    		[PMID: 29856759]
    Huh-7 IC50
    0.3 μM
    Compound: Chemical Probe: LLY-507
    Antiproliferative activity against human Huh-7 cells measured after 7 day by celltitre-glo luminescent assay
    Antiproliferative activity against human Huh-7 cells measured after 7 day by celltitre-glo luminescent assay
    		[PMID: 25825497]
    Huh-7 IC50
    1.5 μM
    Compound: Chemical Probe: LLY-507
    Antiproliferative activity against human Huh-7 cells measured after 3 to 4 day by celltitre-glo luminescent assay
    Antiproliferative activity against human Huh-7 cells measured after 3 to 4 day by celltitre-glo luminescent assay
    		[PMID: 25825497]
    J-RT3-T3-5 IC50
    1.18 μM
    Compound: Chemical probe: LLY-507
    Antiproliferative activity against human J-RT3-T3-5 cells after 10 days
    Antiproliferative activity against human J-RT3-T3-5 cells after 10 days
    		[PMID: 29856759]
    J82 IC50
    3.15 μM
    Compound: Chemical probe: LLY-507
    Antiproliferative activity against human J82 cells after 10 days
    Antiproliferative activity against human J82 cells after 10 days
    		[PMID: 29856759]
    JAR IC50
    2.88 μM
    Compound: Chemical probe: LLY-507
    Antiproliferative activity against human JAR cells after 10 days
    Antiproliferative activity against human JAR cells after 10 days
    		[PMID: 29856759]
    JEG-3 IC50
    1.5 μM
    Compound: Chemical probe: LLY-507
    Antiproliferative activity against human JEG-3 cells after 10 days
    Antiproliferative activity against human JEG-3 cells after 10 days
    		[PMID: 29856759]
    Jurkat IC50
    0.925 μM
    Compound: Chemical probe: LLY-507
    Antiproliferative activity against human Jurkat cells after 10 days
    Antiproliferative activity against human Jurkat cells after 10 days
    		[PMID: 29856759]
    K562 IC50
    3.21 μM
    Compound: Chemical probe: LLY-507
    Antiproliferative activity against human K562 cells after 10 days
    Antiproliferative activity against human K562 cells after 10 days
    		[PMID: 29856759]
    KLE IC50
    3.21 μM
    Compound: Chemical probe: LLY-507
    Antiproliferative activity against human KLE cells after 10 days
    Antiproliferative activity against human KLE cells after 10 days
    		[PMID: 29856759]
    KYSE-140 IC50
    0.3 μM
    Compound: Chemical Probe: LLY-507
    Antiproliferative activity against human KYSE-140 cells measured after 7 day by celltitre-glo luminescent assay
    Antiproliferative activity against human KYSE-140 cells measured after 7 day by celltitre-glo luminescent assay
    		[PMID: 25825497]
    KYSE-140 IC50
    1.5 μM
    Compound: Chemical Probe: LLY-507
    Antiproliferative activity against human KYSE-140 cells measured after 3 to 4 day by celltitre-glo luminescent assay
    Antiproliferative activity against human KYSE-140 cells measured after 3 to 4 day by celltitre-glo luminescent assay
    		[PMID: 25825497]
    KYSE-270 IC50
    0.3 μM
    Compound: Chemical Probe: LLY-507
    Antiproliferative activity against human KYSE-270 cells measured after 7 day by celltitre-glo luminescent assay
    Antiproliferative activity against human KYSE-270 cells measured after 7 day by celltitre-glo luminescent assay
    		[PMID: 25825497]
    KYSE-270 IC50
    1.5 μM
    Compound: 3; LLY-507
    Antitumor activity against human KYSE-270 cells assessed as inhibition of cell proliferation incubated for 3 to 7 days by CellTiter-Glo assay
    Antitumor activity against human KYSE-270 cells assessed as inhibition of cell proliferation incubated for 3 to 7 days by CellTiter-Glo assay
    		[PMID: 35914250]
    KYSE-270 IC50
    1.5 μM
    Compound: Chemical Probe: LLY-507
    Antiproliferative activity against human KYSE-270 cells measured after 3 to 4 day by celltitre-glo luminescent assay
    Antiproliferative activity against human KYSE-270 cells measured after 3 to 4 day by celltitre-glo luminescent assay
    		[PMID: 25825497]
    KYSE-30 IC50
    0.3 μM
    Compound: Chemical Probe: LLY-507
    Antiproliferative activity against human KYSE-30 cells measured after 7 day by celltitre-glo luminescent assay
    Antiproliferative activity against human KYSE-30 cells measured after 7 day by celltitre-glo luminescent assay
    		[PMID: 25825497]
    KYSE-30 IC50
    1.5 μM
    Compound: Chemical Probe: LLY-507
    Antiproliferative activity against human KYSE-30 cells measured after 3 to 4 day by celltitre-glo luminescent assay
    Antiproliferative activity against human KYSE-30 cells measured after 3 to 4 day by celltitre-glo luminescent assay
    		[PMID: 25825497]
    L-428 IC50
    1.49 μM
    Compound: Chemical probe: LLY-507
    Antiproliferative activity against human L-428 cells after 10 days
    Antiproliferative activity against human L-428 cells after 10 days
    		[PMID: 29856759]
    LNCaP IC50
    3.44 μM
    Compound: Chemical probe: LLY-507
    Antiproliferative activity against human LNCaP cells after 10 days
    Antiproliferative activity against human LNCaP cells after 10 days
    		[PMID: 29856759]
    LS-1034 IC50
    2.9 μM
    Compound: Chemical probe: LLY-507
    Antiproliferative activity against human LS1034 cells after 10 days
    Antiproliferative activity against human LS1034 cells after 10 days
    		[PMID: 29856759]
    LS174T IC50
    1.47 μM
    Compound: Chemical probe: LLY-507
    Antiproliferative activity against human LS174T cells after 10 days
    Antiproliferative activity against human LS174T cells after 10 days
    		[PMID: 29856759]
    MC-IXC IC50
    1.92 μM
    Compound: Chemical probe: LLY-507
    Antiproliferative activity against human MC-IXC cells after 10 days
    Antiproliferative activity against human MC-IXC cells after 10 days
    		[PMID: 29856759]
    MCF7 IC50
    0.3 μM
    Compound: Chemical Probe: LLY-507
    Antiproliferative activity against human MCF7 cells measured after 7 day by celltitre-glo luminescent assay
    Antiproliferative activity against human MCF7 cells measured after 7 day by celltitre-glo luminescent assay
    		[PMID: 25825497]
    MCF7 IC50
    1.5 μM
    Compound: Chemical Probe: LLY-507
    Antiproliferative activity against human MCF7 cells measured after 3 to 4 day by celltitre-glo luminescent assay
    Antiproliferative activity against human MCF7 cells measured after 3 to 4 day by celltitre-glo luminescent assay
    		[PMID: 25825497]
    MCF7 IC50
    3.11 μM
    Compound: Chemical probe: LLY-507
    Antiproliferative activity against human MCF7 cells after 10 days
    Antiproliferative activity against human MCF7 cells after 10 days
    		[PMID: 29856759]
    MDA-MB-231 IC50
    0.3 μM
    Compound: Chemical Probe: LLY-507
    Antiproliferative activity against human MDA-MB-231 cells measured after 7 day by celltitre-glo luminescent assay
    Antiproliferative activity against human MDA-MB-231 cells measured after 7 day by celltitre-glo luminescent assay
    		[PMID: 25825497]
    MDA-MB-231 IC50
    1.07 μM
    Compound: Chemical probe: LLY-507
    Antiproliferative activity against human MDA-MB-231 cells after 10 days
    Antiproliferative activity against human MDA-MB-231 cells after 10 days
    		[PMID: 29856759]
    MDA-MB-231 IC50
    1.5 μM
    Compound: Chemical Probe: LLY-507
    Antiproliferative activity against human MDA-MB-231 cells measured after 3 to 4 day by celltitre-glo luminescent assay
    Antiproliferative activity against human MDA-MB-231 cells measured after 3 to 4 day by celltitre-glo luminescent assay
    		[PMID: 25825497]
    MDA-MB-436 IC50
    3.03 μM
    Compound: Chemical probe: LLY-507
    Antiproliferative activity against human MDA-MB-436 cells after 10 days
    Antiproliferative activity against human MDA-MB-436 cells after 10 days
    		[PMID: 29856759]
    MDA-MB-453 IC50
    1.5 μM
    Compound: Chemical probe: LLY-507
    Antiproliferative activity against human MDA-MB-453 cells after 10 days
    Antiproliferative activity against human MDA-MB-453 cells after 10 days
    		[PMID: 29856759]
    MDA-MB-468 IC50
    1.89 μM
    Compound: Chemical probe: LLY-507
    Antiproliferative activity against human MDA-MB-468 cells after 10 days
    Antiproliferative activity against human MDA-MB-468 cells after 10 days
    		[PMID: 29856759]
    MEG-01 IC50
    1.28 μM
    Compound: Chemical probe: LLY-507
    Antiproliferative activity against human MEG-01 cells after 10 days
    Antiproliferative activity against human MEG-01 cells after 10 days
    		[PMID: 29856759]
    MES-SA IC50
    2.3 μM
    Compound: Chemical probe: LLY-507
    Antiproliferative activity against human MES-SA cells after 10 days
    Antiproliferative activity against human MES-SA cells after 10 days
    		[PMID: 29856759]
    MG-63 IC50
    6.12 μM
    Compound: Chemical probe: LLY-507
    Antiproliferative activity against human MG-63 cells after 10 days
    Antiproliferative activity against human MG-63 cells after 10 days
    		[PMID: 29856759]
    MHH-PREB-1 IC50
    1.06 μM
    Compound: Chemical probe: LLY-507
    Antiproliferative activity against human MHH-PREB-1 cells after 10 days
    Antiproliferative activity against human MHH-PREB-1 cells after 10 days
    		[PMID: 29856759]
    MIA PaCa-2 IC50
    2.03 μM
    Compound: Chemical probe: LLY-507
    Antiproliferative activity against human Mia PaCa-2 cells after 10 days
    Antiproliferative activity against human Mia PaCa-2 cells after 10 days
    		[PMID: 29856759]
    MOLT-16 IC50
    1.11 μM
    Compound: Chemical probe: LLY-507
    Antiproliferative activity against human MOLT-16 cells after 10 days
    Antiproliferative activity against human MOLT-16 cells after 10 days
    		[PMID: 29856759]
    MOLT-3 IC50
    1.36 μM
    Compound: Chemical probe: LLY-507
    Antiproliferative activity against human MOLT-3 cells after 10 days
    Antiproliferative activity against human MOLT-3 cells after 10 days
    		[PMID: 29856759]
    MV4-11 IC50
    1.01 μM
    Compound: Chemical probe: LLY-507
    Antiproliferative activity against human MV4-11 cells after 10 days
    Antiproliferative activity against human MV4-11 cells after 10 days
    		[PMID: 29856759]
    MX1 IC50
    0.3 μM
    Compound: Chemical Probe: LLY-507
    Antiproliferative activity against human MX1 cells measured after 7 day by celltitre-glo luminescent assay
    Antiproliferative activity against human MX1 cells measured after 7 day by celltitre-glo luminescent assay
    		[PMID: 25825497]
    MX1 IC50
    1.5 μM
    Compound: Chemical Probe: LLY-507
    Antiproliferative activity against human MX1 cells measured after 3 to 4 day by celltitre-glo luminescent assay
    Antiproliferative activity against human MX1 cells measured after 3 to 4 day by celltitre-glo luminescent assay
    		[PMID: 25825497]
    MX1 IC50
    1.5 μM
    Compound: Chemical probe: LLY-507
    Antiproliferative activity against human MX1 cells after 10 days
    Antiproliferative activity against human MX1 cells after 10 days
    		[PMID: 29856759]
    Malme-3M IC50
    2.4 μM
    Compound: Chemical probe: LLY-507
    Antiproliferative activity against human Malme-3M cells after 10 days
    Antiproliferative activity against human Malme-3M cells after 10 days
    		[PMID: 29856759]
    MeWo IC50
    1.98 μM
    Compound: Chemical probe: LLY-507
    Antiproliferative activity against human MeWo cells after 10 days
    Antiproliferative activity against human MeWo cells after 10 days
    		[PMID: 29856759]
    NALM-6 IC50
    1.14 μM
    Compound: Chemical probe: LLY-507
    Antiproliferative activity against human NALM-6 cells after 10 days
    Antiproliferative activity against human NALM-6 cells after 10 days
    		[PMID: 29856759]
    NCI-H292 IC50
    2.69 μM
    Compound: Chemical probe: LLY-507
    Antiproliferative activity against human NCI-H292 cells after 10 days
    Antiproliferative activity against human NCI-H292 cells after 10 days
    		[PMID: 29856759]
    NCI-H295R IC50
    4.84 μM
    Compound: Chemical probe: LLY-507
    Antiproliferative activity against human NCI-H295R cells after 10 days
    Antiproliferative activity against human NCI-H295R cells after 10 days
    		[PMID: 29856759]
    NCI-H441 IC50
    5.63 μM
    Compound: Chemical probe: LLY-507
    Antiproliferative activity against human NCI-H441 cells after 10 days
    Antiproliferative activity against human NCI-H441 cells after 10 days
    		[PMID: 29856759]
    NCI-H446 IC50
    3.16 μM
    Compound: Chemical probe: LLY-507
    Antiproliferative activity against human NCI-H446 cells after 10 days
    Antiproliferative activity against human NCI-H446 cells after 10 days
    		[PMID: 29856759]
    NCI-H460 IC50
    1.78 μM
    Compound: Chemical probe: LLY-507
    Antiproliferative activity against human NCI-H460 cells after 10 days
    Antiproliferative activity against human NCI-H460 cells after 10 days
    		[PMID: 29856759]
    NCI-H508 IC50
    3.09 μM
    Compound: Chemical probe: LLY-507
    Antiproliferative activity against human NCI-H508 cells after 10 days
    Antiproliferative activity against human NCI-H508 cells after 10 days
    		[PMID: 29856759]
    NCI-H520 IC50
    2.7 μM
    Compound: Chemical probe: LLY-507
    Antiproliferative activity against human NCI-H520 cells after 10 days
    Antiproliferative activity against human NCI-H520 cells after 10 days
    		[PMID: 29856759]
    NCI-H596 IC50
    2.95 μM
    Compound: Chemical probe: LLY-507
    Antiproliferative activity against human NCI-H596 cells after 10 days
    Antiproliferative activity against human NCI-H596 cells after 10 days
    		[PMID: 29856759]
    NCI-H661 IC50
    3.39 μM
    Compound: Chemical probe: LLY-507
    Antiproliferative activity against human NCI-H661 cells after 10 days
    Antiproliferative activity against human NCI-H661 cells after 10 days
    		[PMID: 29856759]
    NCI-H69 IC50
    2.74 μM
    Compound: Chemical probe: LLY-507
    Antiproliferative activity against human NCI-H69 cells after 10 days
    Antiproliferative activity against human NCI-H69 cells after 10 days
    		[PMID: 29856759]
    NCI-H747 IC50
    2.32 μM
    Compound: Chemical probe: LLY-507
    Antiproliferative activity against human NCI-H747 cells after 10 days
    Antiproliferative activity against human NCI-H747 cells after 10 days
    		[PMID: 29856759]
    NCI-N87 IC50
    7 μM
    Compound: LLY-507
    Antiproliferative activity against human NCI-N87 cells
    Antiproliferative activity against human NCI-N87 cells
    		[PMID: 33011288]
    OE19 IC50
    2.52 μM
    Compound: Chemical probe: LLY-507
    Antiproliferative activity against human OE19 cells after 10 days
    Antiproliferative activity against human OE19 cells after 10 days
    		[PMID: 29856759]
    OE33 IC50
    2 μM
    Compound: Chemical probe: LLY-507
    Antiproliferative activity against human OE33 cells after 10 days
    Antiproliferative activity against human OE33 cells after 10 days
    		[PMID: 29856759]
    OVCAR-3 IC50
    3.95 μM
    Compound: Chemical probe: LLY-507
    Antiproliferative activity against human OVCAR-3 cells after 10 days
    Antiproliferative activity against human OVCAR-3 cells after 10 days
    		[PMID: 29856759]
    PANC-1 IC50
    2.87 μM
    Compound: Chemical probe: LLY-507
    Antiproliferative activity against human PANC-1 cells after 10 days
    Antiproliferative activity against human PANC-1 cells after 10 days
    		[PMID: 29856759]
    PC-3 IC50
    2.77 μM
    Compound: Chemical probe: LLY-507
    Antiproliferative activity against human PC-3 cells after 10 days
    Antiproliferative activity against human PC-3 cells after 10 days
    		[PMID: 29856759]
    RD IC50
    0.954 μM
    Compound: Chemical probe: LLY-507
    Antiproliferative activity against human RD cells after 10 days
    Antiproliferative activity against human RD cells after 10 days
    		[PMID: 29856759]
    RKO IC50
    1.04 μM
    Compound: Chemical probe: LLY-507
    Antiproliferative activity against human RKO cells after 10 days
    Antiproliferative activity against human RKO cells after 10 days
    		[PMID: 29856759]
    RL95-2 IC50
    1.29 μM
    Compound: Chemical probe: LLY-507
    Antiproliferative activity against human RL95-2 cells after 10 days
    Antiproliferative activity against human RL95-2 cells after 10 days
    		[PMID: 29856759]
    RPMI-6666 IC50
    2.91 μM
    Compound: Chemical probe: LLY-507
    Antiproliferative activity against human RPMI-6666 cells after 10 days
    Antiproliferative activity against human RPMI-6666 cells after 10 days
    		[PMID: 29856759]
    RPMI-7951 IC50
    2.05 μM
    Compound: Chemical probe: LLY-507
    Antiproliferative activity against human RPMI-7951 cells after 10 days
    Antiproliferative activity against human RPMI-7951 cells after 10 days
    		[PMID: 29856759]
    RPMI-8226 IC50
    1.56 μM
    Compound: Chemical probe: LLY-507
    Antiproliferative activity against human RPMI-8226 cells after 10 days
    Antiproliferative activity against human RPMI-8226 cells after 10 days
    		[PMID: 29856759]
    Raji IC50
    1.59 μM
    Compound: Chemical probe: LLY-507
    Antiproliferative activity against human Raji cells after 10 days
    Antiproliferative activity against human Raji cells after 10 days
    		[PMID: 29856759]
    Ramos IC50
    1.04 μM
    Compound: Chemical probe: LLY-507
    Antiproliferative activity against human Ramos cells after 10 days
    Antiproliferative activity against human Ramos cells after 10 days
    		[PMID: 29856759]
    SAOS-2 IC50
    3.03 μM
    Compound: Chemical probe: LLY-507
    Antiproliferative activity against human SAOS-2 cells after 10 days
    Antiproliferative activity against human SAOS-2 cells after 10 days
    		[PMID: 29856759]
    SCC-25 IC50
    2.52 μM
    Compound: Chemical probe: LLY-507
    Antiproliferative activity against human SCC-25 cells after 10 days
    Antiproliferative activity against human SCC-25 cells after 10 days
    		[PMID: 29856759]
    SCC-4 IC50
    3.59 μM
    Compound: Chemical probe: LLY-507
    Antiproliferative activity against human SCC-4 cells after 10 days
    Antiproliferative activity against human SCC-4 cells after 10 days
    		[PMID: 29856759]
    SCC-9 IC50
    1.18 μM
    Compound: Chemical probe: LLY-507
    Antiproliferative activity against human SCC-9 cells after 10 days
    Antiproliferative activity against human SCC-9 cells after 10 days
    		[PMID: 29856759]
    SCaBER IC50
    1.5 μM
    Compound: Chemical probe: LLY-507
    Antiproliferative activity against human SCaBER cells after 10 days
    Antiproliferative activity against human SCaBER cells after 10 days
    		[PMID: 29856759]
    SH-4 IC50
    1.15 μM
    Compound: Chemical probe: LLY-507
    Antiproliferative activity against human SH-4 cells after 10 days
    Antiproliferative activity against human SH-4 cells after 10 days
    		[PMID: 29856759]
    SHP77 IC50
    1.65 μM
    Compound: Chemical probe: LLY-507
    Antiproliferative activity against human SHP77 cells after 10 days
    Antiproliferative activity against human SHP77 cells after 10 days
    		[PMID: 29856759]
    SJRH30 IC50
    1.23 μM
    Compound: Chemical probe: LLY-507
    Antiproliferative activity against human SJRH30 cells after 10 days
    Antiproliferative activity against human SJRH30 cells after 10 days
    		[PMID: 29856759]
    SJSA-1 IC50
    1.47 μM
    Compound: Chemical probe: LLY-507
    Antiproliferative activity against human SJSA-1 cells after 10 days
    Antiproliferative activity against human SJSA-1 cells after 10 days
    		[PMID: 29856759]
    SK-BR-3 IC50
    1.17 μM
    Compound: Chemical probe: LLY-507
    Antiproliferative activity against human SK-BR-3 cells after 10 days
    Antiproliferative activity against human SK-BR-3 cells after 10 days
    		[PMID: 29856759]
    SK-HEP1 IC50
    0.3 μM
    Compound: Chemical Probe: LLY-507
    Antiproliferative activity against human SK-HEP1 cells measured after 7 day by celltitre-glo luminescent assay
    Antiproliferative activity against human SK-HEP1 cells measured after 7 day by celltitre-glo luminescent assay
    		[PMID: 25825497]
    SK-HEP1 IC50
    1.5 μM
    Compound: Chemical Probe: LLY-507
    Antiproliferative activity against human SK-HEP1 cells measured after 3 to 4 day by celltitre-glo luminescent assay
    Antiproliferative activity against human SK-HEP1 cells measured after 3 to 4 day by celltitre-glo luminescent assay
    		[PMID: 25825497]
    SK-LMS-1 IC50
    2.41 μM
    Compound: Chemical probe: LLY-507
    Antiproliferative activity against human SK-LMS-1 cells after 10 days
    Antiproliferative activity against human SK-LMS-1 cells after 10 days
    		[PMID: 29856759]
    SK-MEL-1 IC50
    1.9 μM
    Compound: Chemical probe: LLY-507
    Antiproliferative activity against human SK-MEL-1 cells after 10 days
    Antiproliferative activity against human SK-MEL-1 cells after 10 days
    		[PMID: 29856759]
    SK-MEL-28 IC50
    1.77 μM
    Compound: Chemical probe: LLY-507
    Antiproliferative activity against human SK-MEL-28 cells after 10 days
    Antiproliferative activity against human SK-MEL-28 cells after 10 days
    		[PMID: 29856759]
    SK-MEL3 IC50
    1.39 μM
    Compound: Chemical probe: LLY-507
    Antiproliferative activity against human SK-MEL3 cells after 10 days
    Antiproliferative activity against human SK-MEL3 cells after 10 days
    		[PMID: 29856759]
    SK-MES-1 IC50
    1.18 μM
    Compound: Chemical probe: LLY-507
    Antiproliferative activity against human SK-MES-1 cells after 10 days
    Antiproliferative activity against human SK-MES-1 cells after 10 days
    		[PMID: 29856759]
    SK-N-AS IC50
    1.81 μM
    Compound: Chemical probe: LLY-507
    Antiproliferative activity against human SK-N-AS cells after 10 days
    Antiproliferative activity against human SK-N-AS cells after 10 days
    		[PMID: 29856759]
    SK-N-DZ IC50
    3.76 μM
    Compound: Chemical probe: LLY-507
    Antiproliferative activity against human SK-N-DZ cells after 10 days
    Antiproliferative activity against human SK-N-DZ cells after 10 days
    		[PMID: 29856759]
    SK-N-FI IC50
    6.03 μM
    Compound: Chemical probe: LLY-507
    Antiproliferative activity against human SK-N-FI cells after 10 days
    Antiproliferative activity against human SK-N-FI cells after 10 days
    		[PMID: 29856759]
    SK-NEP-1 IC50
    3.18 μM
    Compound: Chemical probe: LLY-507
    Antiproliferative activity against human SK-NEP-1 cells after 10 days
    Antiproliferative activity against human SK-NEP-1 cells after 10 days
    		[PMID: 29856759]
    SK-OV-3 IC50
    2.95 μM
    Compound: Chemical probe: LLY-507
    Antiproliferative activity against human SK-OV-3 cells after 10 days
    Antiproliferative activity against human SK-OV-3 cells after 10 days
    		[PMID: 29856759]
    SK-UT-1 IC50
    1.41 μM
    Compound: Chemical probe: LLY-507
    Antiproliferative activity against human SK-UT-1 cells after 10 days
    Antiproliferative activity against human SK-UT-1 cells after 10 days
    		[PMID: 29856759]
    SNB-19 IC50
    2.52 μM
    Compound: Chemical probe: LLY-507
    Antiproliferative activity against human SNB-19 cells after 10 days
    Antiproliferative activity against human SNB-19 cells after 10 days
    		[PMID: 29856759]
    SNU-16 IC50
    0.993 μM
    Compound: Chemical probe: LLY-507
    Antiproliferative activity against human SNU-16 cells after 10 days
    Antiproliferative activity against human SNU-16 cells after 10 days
    		[PMID: 29856759]
    SNU-423 IC50
    1.11 μM
    Compound: Chemical probe: LLY-507
    Antiproliferative activity against human SNU-423 cells after 10 days
    Antiproliferative activity against human SNU-423 cells after 10 days
    		[PMID: 29856759]
    SNU-449 IC50
    0.3 μM
    Compound: Chemical Probe: LLY-507
    Antiproliferative activity against human SNU-449 cells measured after 7 day by celltitre-glo luminescent assay
    Antiproliferative activity against human SNU-449 cells measured after 7 day by celltitre-glo luminescent assay
    		[PMID: 25825497]
    SNU-449 IC50
    1.5 μM
    Compound: Chemical Probe: LLY-507
    Antiproliferative activity against human SNU-449 cells measured after 3 to 4 day by celltitre-glo luminescent assay
    Antiproliferative activity against human SNU-449 cells measured after 3 to 4 day by celltitre-glo luminescent assay
    		[PMID: 25825497]
    SNU-5 IC50
    3.32 μM
    Compound: Chemical probe: LLY-507
    Antiproliferative activity against human SNU-5 cells after 10 days
    Antiproliferative activity against human SNU-5 cells after 10 days
    		[PMID: 29856759]
    SNU1 IC50
    1.19 μM
    Compound: Chemical probe: LLY-507
    Antiproliferative activity against human SNU1 cells after 10 days
    Antiproliferative activity against human SNU1 cells after 10 days
    		[PMID: 29856759]
    SR IC50
    0.708 μM
    Compound: Chemical probe: LLY-507
    Antiproliferative activity against human SR cells after 10 days
    Antiproliferative activity against human SR cells after 10 days
    		[PMID: 29856759]
    ST486 IC50
    0.955 μM
    Compound: Chemical probe: LLY-507
    Antiproliferative activity against human ST486 cells after 10 days
    Antiproliferative activity against human ST486 cells after 10 days
    		[PMID: 29856759]
    SU.86.86 IC50
    3.55 μM
    Compound: Chemical probe: LLY-507
    Antiproliferative activity against human SU-86-86 cells after 10 days
    Antiproliferative activity against human SU-86-86 cells after 10 days
    		[PMID: 29856759]
    SW 954 IC50
    4.07 μM
    Compound: Chemical probe: LLY-507
    Antiproliferative activity against human SW 954 cells after 10 days
    Antiproliferative activity against human SW 954 cells after 10 days
    		[PMID: 29856759]
    SW 962 IC50
    3.38 μM
    Compound: Chemical probe: LLY-507
    Antiproliferative activity against human SW 962 cells after 10 days
    Antiproliferative activity against human SW 962 cells after 10 days
    		[PMID: 29856759]
    SW-620 IC50
    3.08 μM
    Compound: Chemical probe: LLY-507
    Antiproliferative activity against human SW620 cells after 10 days
    Antiproliferative activity against human SW620 cells after 10 days
    		[PMID: 29856759]
    SW1088 IC50
    1.18 μM
    Compound: Chemical probe: LLY-507
    Antiproliferative activity against human SW1088 cells after 10 days
    Antiproliferative activity against human SW1088 cells after 10 days
    		[PMID: 29856759]
    SW13 IC50
    2.68 μM
    Compound: Chemical probe: LLY-507
    Antiproliferative activity against human SW13 cells after 10 days
    Antiproliferative activity against human SW13 cells after 10 days
    		[PMID: 29856759]
    SW1353 IC50
    2.98 μM
    Compound: Chemical probe: LLY-507
    Antiproliferative activity against human SW1353 cells after 10 days
    Antiproliferative activity against human SW1353 cells after 10 days
    		[PMID: 29856759]
    SW1417 IC50
    3.23 μM
    Compound: Chemical probe: LLY-507
    Antiproliferative activity against human SW1417 cells after 10 days
    Antiproliferative activity against human SW1417 cells after 10 days
    		[PMID: 29856759]
    SW1463 IC50
    3.06 μM
    Compound: Chemical probe: LLY-507
    Antiproliferative activity against human SW1463 cells after 10 days
    Antiproliferative activity against human SW1463 cells after 10 days
    		[PMID: 29856759]
    SW1783 IC50
    2.96 μM
    Compound: Chemical probe: LLY-507
    Antiproliferative activity against human SW1783 cells after 10 days
    Antiproliferative activity against human SW1783 cells after 10 days
    		[PMID: 29856759]
    SW48 IC50
    1.35 μM
    Compound: Chemical probe: LLY-507
    Antiproliferative activity against human SW48 cells after 10 days
    Antiproliferative activity against human SW48 cells after 10 days
    		[PMID: 29856759]
    SW480 IC50
    2.15 μM
    Compound: Chemical probe: LLY-507
    Antiproliferative activity against human SW480 cells after 10 days
    Antiproliferative activity against human SW480 cells after 10 days
    		[PMID: 29856759]
    SW684 IC50
    5.75 μM
    Compound: Chemical probe: LLY-507
    Antiproliferative activity against human SW684 cells after 10 days
    Antiproliferative activity against human SW684 cells after 10 days
    		[PMID: 29856759]
    SW837 IC50
    3.69 μM
    Compound: Chemical probe: LLY-507
    Antiproliferative activity against human SW837 cells after 10 days
    Antiproliferative activity against human SW837 cells after 10 days
    		[PMID: 29856759]
    SW872 IC50
    2.53 μM
    Compound: Chemical probe: LLY-507
    Antiproliferative activity against human SW872 cells after 10 days
    Antiproliferative activity against human SW872 cells after 10 days
    		[PMID: 29856759]
    SW900 IC50
    3.22 μM
    Compound: Chemical probe: LLY-507
    Antiproliferative activity against human SW900 cells after 10 days
    Antiproliferative activity against human SW900 cells after 10 days
    		[PMID: 29856759]
    SW948 IC50
    3.91 μM
    Compound: Chemical probe: LLY-507
    Antiproliferative activity against human SW948 cells after 10 days
    Antiproliferative activity against human SW948 cells after 10 days
    		[PMID: 29856759]
    SW982 IC50
    5.79 μM
    Compound: Chemical probe: LLY-507
    Antiproliferative activity against human SW982 cells after 10 days
    Antiproliferative activity against human SW982 cells after 10 days
    		[PMID: 29856759]
    SiHa IC50
    3.26 μM
    Compound: Chemical probe: LLY-507
    Antiproliferative activity against human SiHa cells after 10 days
    Antiproliferative activity against human SiHa cells after 10 days
    		[PMID: 29856759]
    T-24 IC50
    2.94 μM
    Compound: Chemical probe: LLY-507
    Antiproliferative activity against human T24 cells after 10 days
    Antiproliferative activity against human T24 cells after 10 days
    		[PMID: 29856759]
    T47D IC50
    2.22 μM
    Compound: Chemical probe: LLY-507
    Antiproliferative activity against human T47D cells after 10 days
    Antiproliferative activity against human T47D cells after 10 days
    		[PMID: 29856759]
    T98G IC50
    5.87 μM
    Compound: Chemical probe: LLY-507
    Antiproliferative activity against human T98G cells after 10 days
    Antiproliferative activity against human T98G cells after 10 days
    		[PMID: 29856759]
    TCC-SUP IC50
    2.26 μM
    Compound: Chemical probe: LLY-507
    Antiproliferative activity against human TCC-SUP cells after 10 days
    Antiproliferative activity against human TCC-SUP cells after 10 days
    		[PMID: 29856759]
    THP-1 IC50
    2.86 μM
    Compound: Chemical probe: LLY-507
    Antiproliferative activity against human THP-1 cells after 10 days
    Antiproliferative activity against human THP-1 cells after 10 days
    		[PMID: 29856759]
    TOV21G IC50
    1.2 μM
    Compound: LLY-507
    Anti-proliferative activity against human TOV-21G cells assessed as cell viability incubated for 24 hrs by CCK-8 assay
    Anti-proliferative activity against human TOV-21G cells assessed as cell viability incubated for 24 hrs by CCK-8 assay
    		[PMID: 32934721]
    U-266 IC50
    1.26 μM
    Compound: Chemical probe: LLY-507
    Antiproliferative activity against human U266B1 cells after 10 days
    Antiproliferative activity against human U266B1 cells after 10 days
    		[PMID: 29856759]
    U-87MG ATCC IC50
    2.85 μM
    Compound: Chemical probe: LLY-507
    Antiproliferative activity against human U-87MG cells after 10 days
    Antiproliferative activity against human U-87MG cells after 10 days
    		[PMID: 29856759]
    U138-MG IC50
    4.54 μM
    Compound: Chemical probe: LLY-507
    Antiproliferative activity against human U138-MG cells after 10 days
    Antiproliferative activity against human U138-MG cells after 10 days
    		[PMID: 29856759]
    U2OS IC50
    1.68 μM
    Compound: Chemical probe: LLY-507
    Antiproliferative activity against human U2OS cells after 10 days
    Antiproliferative activity against human U2OS cells after 10 days
    		[PMID: 29856759]
    U2OS IC50
    600 nM
    Compound: 2; LLY-507
    Inhibition of SMYD2 (unknown origin) expressed in human U2OS cells assessed as reduction in p53 methylation by Western blot analysis
    Inhibition of SMYD2 (unknown origin) expressed in human U2OS cells assessed as reduction in p53 methylation by Western blot analysis
    		[PMID: 27075367]
    UACC-812 IC50
    0.3 μM
    Compound: Chemical Probe: LLY-507
    Antiproliferative activity against human UACC-812 cells measured after 7 day by celltitre-glo luminescent assay
    Antiproliferative activity against human UACC-812 cells measured after 7 day by celltitre-glo luminescent assay
    		[PMID: 25825497]
    UACC-812 IC50
    1.5 μM
    Compound: Chemical Probe: LLY-507
    Antiproliferative activity against human UACC-812 cells measured after 3 to 4 day by celltitre-glo luminescent assay
    Antiproliferative activity against human UACC-812 cells measured after 3 to 4 day by celltitre-glo luminescent assay
    		[PMID: 25825497]
    UACC-893 IC50
    0.3 μM
    Compound: Chemical Probe: LLY-507
    Antiproliferative activity against human UACC-893 cells measured after 7 day by celltitre-glo luminescent assay
    Antiproliferative activity against human UACC-893 cells measured after 7 day by celltitre-glo luminescent assay
    		[PMID: 25825497]
    UACC-893 IC50
    1.5 μM
    Compound: Chemical Probe: LLY-507
    Antiproliferative activity against human UACC-893 cells measured after 3 to 4 day by celltitre-glo luminescent assay
    Antiproliferative activity against human UACC-893 cells measured after 3 to 4 day by celltitre-glo luminescent assay
    		[PMID: 25825497]
    UMUC3 IC50
    2.91 μM
    Compound: Chemical probe: LLY-507
    Antiproliferative activity against human UM-UC-3 cells after 10 days
    Antiproliferative activity against human UM-UC-3 cells after 10 days
    		[PMID: 29856759]
    WiDr IC50
    0.838 μM
    Compound: Chemical probe: LLY-507
    Antiproliferative activity against human WiDr cells after 10 days
    Antiproliferative activity against human WiDr cells after 10 days
    		[PMID: 29856759]
    Y79 IC50
    3.53 μM
    Compound: Chemical probe: LLY-507
    Antiproliferative activity against human Y79 cells after 10 days
    Antiproliferative activity against human Y79 cells after 10 days
    		[PMID: 29856759]
    YAPC IC50
    2.87 μM
    Compound: Chemical probe: LLY-507
    Antiproliferative activity against human YAPC cells after 10 days
    Antiproliferative activity against human YAPC cells after 10 days
    		[PMID: 29856759]
    体外研究
    (In Vitro)

    LLY-507 对 SMYD2 的选择性超过 21 种其他甲基转移酶，包括 SMYD3[1]。
    LLY-507 结合 SMYD2 的底物通道并支持其抑制的选择性[1]。
    LY-507 能够有效抑制 SMYD2 酶对 H4 肽的甲基化作用，IC50 为 31 nM[1]。
    LLY-507 (0.03 -20 μM；28 小时) 抑制 U2OS 细胞中 SMYD2 介导的 p53 Lys370 甲基化，IC50 0.6 μM[1]。
    LLY-507 (0 -20 μM；3-7 天) 抑制多种 ESCC、HCC 和乳腺癌细胞系的增殖[1]。

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    LLY-507 相关抗体:

    Cell Proliferation Assay[1]

    Cell Line: ESCC, HCC, breast cancer cell lines
    Concentration: 0-20 μM
    Incubation Time: 3 days, 7 days
    Result: Inhibited tumor cell proliferation.

    Western Blot Analysis[1]

    Cell Line: HEK293 cells
    Concentration: 0.03 μM, 0.07 μM, 0.15 μM, 0.3 μM, 0.6 μM, 1.25 μM, 2.5 μM
    Incubation Time: 28 hours
    Result: Inhibited SMYD2-mediated methylation of p53 Lys370 in cells.
    分子量

    574.76

    Formula

    C36H42N6O
    CAS 号
    性状

    固体

    颜色

    White to off-white

    运输条件

    Room temperature in continental US; may vary elsewhere.
    储存方式
    Powder -20°C 3 years
    4°C 2 years
    In solvent -80°C 2 years
    -20°C 1 year
    溶解性数据
    细胞实验： 

    DMSO 中的溶解度 : 15 mg/mL (26.10 mM; 超声加热助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

    配制储备液
    浓度 溶剂体积 质量 1 mg 5 mg 10 mg
    1 mM 1.7399 mL 8.6993 mL 17.3986 mL
    5 mM 0.3480 mL 1.7399 mL 3.4797 mL
    查看完整储备液配制表

    * 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
    储备液的保存方式和期限：-80°C, 2 years; -20°C, 1 year。-80°C储存时，请在2年内使用， -20°C储存时，请在1年内使用。

    • 摩尔计算器

    • 稀释计算器

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    质量
    =
    浓度
    ×
    体积
    ×
    分子量 *

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    浓度 (start)

    C1

    ×
    体积 (start)

    V1

    =
    浓度 (final)

    C2

    ×
    体积 (final)

    V2

    动物实验：

    请根据您的 实验动物和给药方式 选择适当的溶解方案。

    以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：
    ——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用；
    以下溶剂前显示的百分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

    • 方案 一

      请依序添加每种溶剂： 10% DMSO    40% PEG300    5% Tween-80    45% Saline

      Solubility: 2.5 mg/mL (4.35 mM); 悬浊液; 超声助溶

      此方案可获得 2.5 mg/mL的均匀悬浊液，悬浊液可用于口服和腹腔注射。

      以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中，混合均匀；再向上述体系中加入 50 μL Tween-80，混合均匀；然后再继续加入 450 μL 生理盐水 定容至 1 mL。

      生理盐水的配制：将 0.9 g 氯化钠，溶解于 ddH₂O 并定容至 100 mL，可以得到澄清透明的生理盐水溶液。
    • 方案 二

      请依序添加每种溶剂： 10% DMSO    90% Corn Oil

      Solubility: ≥ 2.5 mg/mL (4.35 mM); 澄清溶液

      此方案可获得 ≥ 2.5 mg/mL（饱和度未知）的澄清溶液，此方案实验周期在半个月以上的动物实验酌情使用。

      以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中，混合均匀。

    动物溶解方案计算器
    请输入动物实验的基本信息：

    给药剂量

    mg/kg

    动物的平均体重

    g

    每只动物的给药体积

    μL

    动物数量

    只
    由于实验过程有损耗，建议您多配一只动物的量
    请输入您的动物体内配方组成：
    %
    DMSO +
    % 
    +
    %
    Tween-80 +
    %
    Saline
    如果您的动物是免疫缺陷鼠或者体弱鼠，建议 DMSO 中的在最后工作液体系中的占比尽量不超过 2%。
    方案所需 助溶剂 包括：DMSO， ，均可在 MCE 网站选购。 ，Tween 80，均可在 MCE 网站选购。
    计算结果
    工作液所需浓度 : mg/mL
    储备液配制方法 : mg 药物溶于 μL  DMSO（母液浓度为 mg/mL）。
    您所需的储备液浓度超过该产品的实测溶解度，以下方案仅供参考，如有需要，请与 MCE 中国技术支持联系。
    动物实验体内工作液的配制方法 : 取 μL DMSO 储备液，加入 μL 。 μL ，混合均匀至澄清，再加 μL Tween 80，混合均匀至澄清，再加 μL 生理盐水。
    连续给药周期超过半月以上，请谨慎选择该方案。
    请确保第一步储备液溶解至澄清状态，从左到右依次添加助溶剂。您可采用超声加热 （超声清洗仪，建议频次 20-40 kHz），涡旋吹打等方式辅助溶解。
    纯度 & 产品资料
    参考文献

    LLY-507 相关分类

    完整储备液配制表

    * 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
    储备液的保存方式和期限：-80°C, 2 years; -20°C, 1 year。-80°C储存时，请在2年内使用， -20°C储存时，请在1年内使用。

    可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
    DMSO 1 mM 1.7399 mL 8.6993 mL 17.3986 mL 43.4964 mL
    5 mM 0.3480 mL 1.7399 mL 3.4797 mL 8.6993 mL
    10 mM 0.1740 mL 0.8699 mL 1.7399 mL 4.3496 mL
    15 mM 0.1160 mL 0.5800 mL 1.1599 mL 2.8998 mL
    20 mM 0.0870 mL 0.4350 mL 0.8699 mL 2.1748 mL
    25 mM 0.0696 mL 0.3480 mL 0.6959 mL 1.7399 mL
    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    LLY-5071793053-37-8LLY507LLY 507Histone MethyltransferasebreastcancerepigeneticsproteinmethylationSMYD2methyltransferasep53Inhibitorinhibitorinhibit

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